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Source: http://www.facebook.com/thejordantimes/posts/360945203982954
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রবিবার, ২৩ সেপ্টেম্বর, ২০১২
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Cancer Patient Lane Goodwin Achieves Goal, Gets 100K Likes On Facebook
Posted: September 22, 2012
Let?s get a thumbs up for Lane Goodwin.
Goodwin, a 13-year-old boy from Beech Grove, Kentucky who has been battling a rare and aggressive form of cancer, just received his 100,000th like on Facebook.
According to the Courier Press, the idea started after Claudia Wayne, the boy?s aunt, noticed that he gave a thumbs up in nearly all of his pictures. A campaign was started on Facebook, ?The Thumbs-Up For Lane? Campain, and people from around the world have been hitting the like button.
Claudia said:
?Ever since he was diagnosed, he?s never complained, he?s always smiling and in all of the pictures he?s giving a ?thumbs-up? sign? A guy in Virginia started the ?Thumbs-up For Lane? campaign (on Facebook) and it has just taken off.?
Last week Goowin was told that the cancer had spread to his brain.
Claudia said:
?Lane looked at him and said, ?You can?t fix this, can you?? The doctor said, ?No. I can?t.? Lane said, ?That?s OK.? They got him home, and he?s in Beech Grove. He?s in hospice care ? ?(Lane) was smiling and did a thumbs-up for me and hugged me.?He has strength that you can?t imagine ? He has a lot of faith and says he?s ready to go with God.?
The 13-year-old said that one of his wishes was to have 100,000 likes on Facebook. Well, Lane is already way passed that goal. As of now, the Prayers for Lane Goodwin page has 148,531 likes.
In addition to liking the page, people have been sending in photos of themselves giving Lane the thumbs up. The family is also collecting donations for Lane?s treatment as well as selling ?Cancer Bites? t-shirts.
Claudia said:??He?s touched a lot of people?s hearts by making them think about how important family is and how important God is. He?s an amazing young man.?
Source: http://feedproxy.google.com/~r/TheInquisitrTechnology/~3/cXSIKzvyS40/
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শুক্রবার, ২১ সেপ্টেম্বর, ২০১২
Spain borrowing costs ease at auction, relief may be brief
MADRID (Reuters) - Spain's 10-year borrowing costs fell to their lowest level since January in an auction on Thursday, although the relief from market pressure may be short lived as Prime Minister Mariano Rajoy hesitates over seeking an international bailout.
The yield on the benchmark 2022 bond fell to 5.666 percent with almost three times more offered than the amount sold. Demand was also strong for a three-year bond. The Treasury sold a total of 4.8 billion euros ($6.27 billion) in the bonds, above its target.
Investors have been encouraged by the European Central Bank's decision to buy the debt of troubled governments such as Spain's, provided they first request help from the euro zone's rescue funds.
Such a bailout may bring demands for more unpopular austerity, and Rajoy has repeatedly said he is studying an aid request but does not want Europe to dictate conditions.
Markets expect that he will be pushed into a request sooner rather than later, as borrowing costs may start rising again if the ECB purchases fail to materialize.
"The relaxation of the markets is temporary, and if investors start thinking Spain is moving away from a rescue, that would be negative," said Soledad Pellon of IG Markets in Madrid.
Spain is at the heart of the euro zone debt crisis, now in its third year, with investors worried it will not be able to bring down its public deficit and control its debt due to a recession.
The bulk of the debt sold, or 3.9 billion euros, was in the shorter-dated bond, which was in high demand because it would be eligible for purchase by the ECB if Spain asks for a rescue, indicating markets are betting on Spain getting aid.
Market reaction was muted after Thursday's auction. The spread between yields on Spanish and Germany benchmark bonds, which is a measure of the perceived risk of investing in Spain, widened from Wednesday's close to 427 basis points. This was still way off a July peak of well over 600 basis points.
The yield on Spain's ten-year bond on the secondary market was up around 8 basis points on the day at 5.8 percent, some way down from a peak over 7.5 percent hit in July.
With many of Spain's 17 regions unable to meet debt payments this year, the central government is stepping in and bailing them out to the tune of 18 billion euros, putting further tension on finances.
Frustration over taxes and separatist sentiment are growing in cash-strapped Catalonia, a powerful northeastern region that generates a fifth of Spain's economic output, has its own language and is largely self-governing.
The leader of Catalonia's regional government, Artur Mas, hinted on Thursday at holding early elections after his call for grater tax autonomy was rejected by Rajoy in a meeting between the two in Madrid.
RESCUE WOULD HELP CREDIT RATING
As well as reassuring investors Spain could meet its debt repayments, a bailout would mean more rigorous control of its budget after it consistently missed deficit targets in recent years, analysts say.
Spain's credit is rated one notch above junk grade by the Moody's agency, which is due to complete a review of Spain by the end of the month.
Rival Standard & Poor's said on Wednesday it was unlikely to cut Spain's rating below investment grade in the near future given the lifeline promised by the ECB's new bond-buying program.
Spain has now raised 82 percent of its planned medium- and long-term borrowing for this year. However, it faces a refinancing hump of 27.5 billion euros in October and will need to raise an additional 10 billions euros to compensate for falling revenues and soaring unemployment and pensions payments.
It has increasingly depended on domestic banks to buy its debt at auctions. That reliance would be reduced if it sought a rescue package.
Spain has already requested 100 billion euros of aid for its banks, crippled when a property bubble burst. Rajoy's government has committed to austerity measures worth 10 percent of gross domestic product up to the end of 2014 and believes more would lead to a public backlash.
But a fresh jump in yields, more calls for cash from indebted regional governments or problems hitting this year's EU-agreed deficit targets could all push Spain into seeking ECB and European aid despite its hesitancy over the conditions.
"The funding costs have come down significantly, almost 1 percentage point on the 10-year, so it's another hurdle the Treasury has overcome. Still, markets expect Spain will request a rescue package at some point," said Luca Cazzulani, deputy head of fixed income at UniCredit.
ECB Governing Council member Luc Coene warned Rajoy on Monday not to delay triggering the program, which would involve requesting aid from the euro zone's new ESM bailout fund, and risk another rapid rise in yields.
(Additional reporting by Robert Hetz and Carlos Ruano; Writing by Fiona Ortiz; Editing by Julien Toyer, Janet McBride and David Stamp)
Source: http://news.yahoo.com/spain-borrowing-costs-ease-auction-relief-may-brief-163333084--business.html
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Defending graffiti, and debating Egypt's future
CAIRO (AP) ? Under cover of darkness, a few municipality workers quietly began to paint over an icon of Egypt's revolution: a giant, elaborate public mural on the street that saw some of the most violent clashes between protesters and police over the past two years.
The mural, stretching three blocks along a wall off Cairo's Tahrir Square, has been a sort of open-air museum of the history of the revolution and its goals ? with "martyr" portraits of slain protesters, graffiti, jokes, freedom slogans and pharaonic, Muslim, Christian and nationalist images to show Egypt's mixed heritage and a history of struggle.
Word of the whitewash quickly got out. A number of progressive, young revolutionaries showed up to defend the murals. In the dead of night, they began to film the workers as they painted under the guard of police, hoping to embarrass them. They talked with the painters about what the murals meant.
The scene on Mohammed Mahmoud Street in the early hours Wednesday was a small but telling counterpoint to last week's angry protests at the U.S. Embassy, led by ultraconservative Islamists protesting an anti-Islam film. Those protests took place only a few blocks away on another street off Tahrir.
Together, the scenes point to the competition over the identity of the new Egypt, over what the country stands for now and what can be expressed.
The mix of largely secular activists who launched the revolt against longtime leader Hosni Mubarak last year say the "revolution" is still continuing, until the country breaks with its authoritarian past and brings freedoms and economic justice.
The Islamists, who rode to power after Mubarak's ouster, have their own vision for Egypt, which they say should adhere to an "Islamic identity" as they define it and preserve traditions.
The government says it has launched a campaign to beautify Tahrir Square, the center of anti-Mubarak protests. But activists saw it as a government attempt to blot out the calls for continued revolution and to assert that a new and stable system is now in place, under elected Islamist President Mohammed Morsi.
"They are erasing history," Gamal Abdel-Nasser, the father of a 19-year old killed during the early days of anti-Mubarak protests, said as he stood at the mural street. "This is not my government. It doesn't represent me."
And for some, repainting the wall just underlined the feeling that the Islamists have snatched the prizes of the revolution.
"This is not about the wall. It is about everything happening in Egypt," said Nazly Hussein, one of the first to arrive at the scene to protest the paint job with a camera, live streaming the workers as they covered murals. "It is about territory they took away from us."
The anti-film protests, she said, showed how under Morsi's three-month-old rule progressives were still having to fight for basic issues like freedom of expression. She pointed to government crackdowns on strikes and the recent sentencing of a Coptic Christian to six years in prison for insulting the Prophet Muhammad and President Morsi. Still unaddressed are bigger goals of the revolution.
"This is about lowering our ceiling. Our real battle is about freedom. Now we are fighting about the right to insult the president or not," she said. "All those on the wall died for bread, freedom and social justice," she said, referring to the martyr portraits.
After the intervention by activists, the municipal workers stopped the whitewashing at daybreak with only half the mural painted over. Graffiti artists moved in to start putting new images on the now white walls. By late Wednesday night, the municipal workers hadn't returned to finish their job, amid a media uproar over the mural erasure.
The first drawing to go up was a portrait of a young man sticking his green tongue as a taunt. "Do it again! Erase, you cowardly regime," was written beneath it.
Graffiti artist Ahmed Nadi painted a new caricature of Morsi, smiling smugly, with the words, "Happy now, Morsi?"
Ali Saleh, a 53-year old security guard at a nearby school, said the murals must stay as a reminder to authorities of the mistakes they committed.
"If we give up the graffiti, this would be the first nail in the coffin," he said. "We are in for a worse dictatorship than Mubarak's."
In an apparent damage control gesture, Morsi's Prime Minister Hesham Kandil said the whitewashing went against "intent to preserve the memory of the revolution," and urged artists to turn Tahrir square into a space that commemorates the revolution's martyrs.
The sense of progressives that the wall is their territory is deepened by its location. Mohammed Mahmoud Street saw dozens killed late last year and early this year as security forces repeatedly tried to crush youth protesting against police brutality and the military rule that followed Mubarak's fall. Morsi's Muslim Brotherhood and other Islamists refused to join the protests.
Several of the activists accused the government and other Islamists of focusing on anger over the film to distract from the lack of real change since Egypt's first free election over the summer brought Morsi to power.
"Is this what will take Egypt forward now? Erasing the graffiti?" a school student in his teens shouted as the artists began to refill the wall with images.
"So long as we can't talk freely in this country, we still need walls to paint and songs to write," said Amr, an 18-year old business student, refusing to give his last name because of security officers who remained nearby.
"We are trying to be free. They don't want us to go down this road. They don't want a thinking people."
Many Egyptians, however, say they just want stability after more than 20 months of turmoil. Some residents of the Mohammed Mahmoud area were happy to see the murals go, ending a reminder of the battles on their doorstep.
"This is ugly," said Nour Nagati, referring to the graffiti of a man with his tongue out. "Paint me a flower, paint me a tree. This is a symbol of stability. But this provocation will only perpetuate provocation."
Another resident in the area, who says he lived in Germany for 20 years and is an agricultural engineer, objected to the new graffiti artists over the words "cowardly regime" they had just scrawled on the wall.
"Why should I wake up and find this profanity scribbled on the walls. I am Egyptian. This is not my culture. This is only for the Westerners," said the man, who wore the small beard of a conservative Muslim. He refused to give his name.
But the lines are not black and white in Egypt: Age can be as much a factor as ideology. A younger man in his 30s with the even longer beard of an ultraconservative Islamist interjected and defended the murals.
"Why the distinction between West and East when it comes to freedom of expression? There is no doubt that whoever represses and breaks up protests is a coward."
The engineer looked at him in surprise, thrown by the idea of an ultraconservative defending graffiti.
"You're mixing everything up!" he cried.
Abdel-Karim Abu Bakr, a passer-by, said the time for using the walls for protest was over.
"We had a revolution, we changed the regime. Let's calm down ... We can't have a revolution every day."
Source: http://news.yahoo.com/defending-graffiti-debating-egypts-future-063449823.html
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Phelps to join Feherty for show ahead of Ryder Cup
FILE - This Sept. 10, 2012 file photo shows Michael Phelps smiling during a celebration of the achievements of Maryland Olympians, in Baltimore. The most decorated Olympian will join David Feherty for a special, Ryder Cup-themed edition of "Feherty Live." The show will air on the Golf Channel on Wednesday, Sept. 26, 2012, two days before the Ryder Cup begins at Medinah in suburban Chicago. (AP Photo/Steve Ruark, File)
FILE - This Sept. 10, 2012 file photo shows Michael Phelps smiling during a celebration of the achievements of Maryland Olympians, in Baltimore. The most decorated Olympian will join David Feherty for a special, Ryder Cup-themed edition of "Feherty Live." The show will air on the Golf Channel on Wednesday, Sept. 26, 2012, two days before the Ryder Cup begins at Medinah in suburban Chicago. (AP Photo/Steve Ruark, File)
ORLANDO, Fla. (AP) ? Michael Phelps is getting another chance to show off his funny side. And he'll have some help from the glibbest man in golf.
The most decorated Olympian will team up with David Feherty for a special Ryder Cup-themed edition of "Feherty Live" next week. The show, which will be taped in front of a live audience, will air on the Golf Channel on Wednesday, two days before the Ryder Cup begins at Medinah in suburban Chicago.
"I'm excited to meet the funniest man in golf, but knowing David, I have a sneaky suspicion that my conversation with him won't be anything like the years of poolside interviews I have done," Phelps said Thursday in a release.
Feherty's sharp wit and relaxed interview style have made him one of the most popular analysts in golf. In the first two seasons of "Feherty," he's interviewed everyone from President Bill Clinton to Hall of Fame basketball player Bill Russell to current world No. 1 Rory McIlroy.
Famous for his intense drive and focus in the pool ? not to mention those 22 Olympic medals ? Phelps showed a lighter side when he hosted "Saturday Night Live" following the Beijing Games. Fans will get to see a lot more of that now that he's retired. In addition to the show with Feherty, Phelps has signed on to be Hank Haney's latest pupil in "The Haney Project."
Haney, the former swing coach of Tiger Woods, has previously worked with actor Ray Romano, Charles Barkley and radio host Rush Limbaugh in the television series, which is in its fifth season. Last year, Haney worked with four celebrities, including former boxing great Sugar Ray Leonard.
"Michael Phelps," Feherty cracked, "may be the only golfer for whom water is not a hazard."
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বৃহস্পতিবার, ২০ সেপ্টেম্বর, ২০১২
'Teen Mom' Farrah: I haven't had sex in two years
MTV
By Ree Hines, TODAY contributor
MTV's original "Teen Mom" series is over now, but one mom isn't through sharing her private life with the public.
Farrah Abraham recently spoke to In Touch magazine and revealed that she's now playing it safe when it comes to sex -- as in, she isn't playing around with it at all.
"I haven?t had sex in two?years," she said. "There are too many risks and emotions involved. It?s always best to wait."
And the mother of 3-year-old Sophia isn't just waiting for sex. She's even steering clear of kisses.
?I don?t believe in kissing someone right away, either,? she revealed to the magazine. ?I?m working very hard in my future to do it right the second time.?
Farrah has claimed that it was her take-it-slow approach that led recent boyfriend John Parra to break up with her.
"I'm happy I chose not to touch him or get serious with some guy who seems controlling and clingy,? she said.
But don't get the wrong idea. Just because Farrah isn't interested in moving fast physically doesn't mean she isn't ready to race to the altar. As "Teen Mom" viewers who watched her interact with ex-beau Daniel Alvarez -- in a decidedly clingy fashion -- know, she certainly seemed ready and willing to wed a man she'd only dated for a few weeks.
In fact, it seemed that her frequent engagement hints coupled with sudden desire for a ring is exactly what led Daniel to decide he'd rather be her ex than current boyfriend.
While some might find that understandable, especially those who watched it all unfold during the show's final season, Farrah feels the fault really was with Daniel.
When "Teen Mom" reunion host Dr. Drew Pinksy asked her about the pressure she put on Daniel, she replied, "He's like, 'Ooh, a ring? Oh, marriage? Oh, more commitment?' Little boy broke."
That's one way to look at it.
Those who want to hear more from Farrah may soon get the chance. The reality TV star recently told Us Weekly that she's close to finalizing a deal for her own spinoff show.
"I'm just closing on it," Abraham said. "It's gonna be just about me and my life."
And she isn't the only "Teen Mom" alum with a spin-off in the works. According to Celebuzz, Catelynn Lowell's father recently confirmed that she and her fianc?, Tyler Baltierra, are filming a show of their own.
Are you surprised by Farrah big reveal? And what about her take on clingy guys, given her own clingy tendencies? Share your thoughts on our Facebook page.
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Einstein-Montefiore scientists awarded 2 NCI 'Provocative Questions' grants
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Public release date: 20-Sep-2012[ | E-mail |
Share ] Contact: Kim Newman
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
September 20, 2012 (BRONX, NY) Why does cancer arise in certain parts of the body and not others? How exactly does it spread? These are critical questions that cannot be answered clearly despite decades of cancer research. Answers to complex but central questions about cancer have long stymied efforts to "win the war" on the disease.
Two research teams at Albert Einstein College of Medicine of Yeshiva University and Montefiore Medical Center , the University Hospital for Einstein, have each been awarded grants from the National Cancer Institute (NCI) as part of their "Provocative Questions" program. The innovative effort is designed to ignite investigations into 24 promising but neglected or unexplored areas of research. Answering the questions would dramatically enhance ongoing efforts to prevent, treat and cure the disease.
The Einstein-Montefiore grants two of only 57 given nationwide and only five in New York City, and totaling more than $3 million over the next five years are aimed at determining why cancer arises in certain tissues and how the disease spreads. Grant recipients are Steven Libutti, M.D. , Richard Kitsis, M.D. , John Condeelis, Ph.D. , Sumanta Goswami, Ph.D., and Maja Oktay, M.D., Ph.D.
Both research teams will leverage the shared resources and unique assets of the two institutions to tackle their research projects, tapping into the clinical opportunities at Montefiore Einstein Center for Cancer Care and the advanced technical resources at the Albert Einstein Cancer Center and the Gruss Lipper Biophotonics Center .
The first grant, awarded to Drs. Libutti and Kitsis, will investigate why certain mutations promote cancer in some tissues of the body but not in others. The researchers will try to identify the factors responsible for this phenomenon, which they call "tissue-selective tumorigenesis."
The model they'll be using in their study is a rare condition that results in human cancer called multiple endocrine neoplasia type 1 (MEN1). This inherited cancer results from a mutation in a gene called MEN1. Since MEN1 is a tumor suppressor gene, mutations in this gene permit tumors to occur. People with this cancer have a mutated MEN1 gene in every cell of their body, yet their tumors occur only in their endocrine glands (most often the parathyroid glands, the pancreas and the pituitary gland) and their duodenum (small intestine). The goal of this study is to discover why.
The researchers will take advantage of unique mouse models they developed and the fact that MEN1 tumors form only in the portion of the pancreas that produces insulin and other hormones and never in the "non-endocrine" part of the organ. Therefore, part of their research will involve comparing the two types of pancreatic tissue, looking for differences in gene expression.
The second team of grant recipients, consisting of Drs. Condeelis, Goswami and Oktay, will focus on developing new approaches to investigating the biology of metastasisthe usually fatal spread of the primary cancer to other parts of the body. Using human breast cancer cells obtained from tumors of patients treated at Montefiore Einstein Center for Cancer Care, the scientists will focus on intravasationthe crucial step in which tumor cells invade blood vessels and are then carried to distant sites where they become seeded in new tissues.
The researchers have hypothesized that different breast tumors contain varying proportions of cells capable of invading blood vessels and that these "intravasation-competent" cancer cells have distinct gene expression profiles. The proportion of such tumor cells and the genes they express would determine whether a breast tumor metastasizes or not.
The goal of the research is to develop a human intravasation "signature" that will predict whether a breast cancer tumor is destined to metastasize. Identifying this signature will help to reveal targets for anti-metastatic therapies. Such therapies are urgently needed to decrease the morbidity and mortality associated with breast cancer.
Dr. Libutti is director of the Montefiore Einstein Center for Cancer Care, associate director of clinical services at Albert Einstein Cancer Center , professor of surgery and of genetics at Einstein, and vice chair of surgery at Einstein and Montefiore. Dr. Kitsis holds the Dr. Gerald and Myra Dorros Chair in Cardiovascular Disease and is professor of medicine and of cell biology and the director of the Wilf Family Cardiovascular Research Institute at Einstein. Dr. Condeelis is professor and co-chair of anatomy and structural biology , co-director of the Gruss Lipper Biophotonics Center , leader of the program in tumor microenvironment and metastasis in the Albert Einstein Cancer Center , and holder of the Judith and Burton P. Resnick Chair in Translational Research at Einstein. Dr. Goswami is assistant professor of anatomy and structural biology at Einstein and associate professor of biology at Yeshiva University. Dr. Oktay is associate professor of pathology (clinical) at Einstein and attending physician, pathology at Montefiore.
The MEN1 grant (CA170911) is for $1.7 million over 5 years; the metastasis grant (CA170507) totals $1.4 million over 4 years. The preliminary work for the MEN1 grant was funded by a generous gift from Linda and Earle Altman to Dr. Libutti. The preliminary data that made the metastasis grant possible were obtained from a gift from the Dempsey Family to the Albert Einstein Cancer Center that was awarded to Dr. Oktay in the fall of 2011.
###
Albert Einstein College of Medicine
Albert Einstein College of Medicine of Yeshiva University is one of the nation's premier centers for research, medical education and clinical investigation. In 2011, Einstein received nearly $170 million in awards from the NIH for major research centers at Einstein in diabetes, cancer, liver disease, and AIDS, as well as other areas. Through its affiliation with Montefiore Medical Center, the University Hospital for Einstein, and six other hospital systems, the College of Medicine runs one of the largest post-graduate medical training programs in the United States, offering 155 residency programs to more than 2,200 physicians in training. For more information, please visit www.einstein.yu.edu and follow us on Twitter @EinsteinMed.
Montefiore Medical Center
As the University Hospital for Albert Einstein College of Medicine, Montefiore is a premier academic medical center nationally renowned for its clinical excellence, scientific discovery and commitment to its community. Montefiore is consistently recognized among the top hospitals nationally by U.S. News & World Report, and excels at educating tomorrow's healthcare professionals in superior clinical and humanistic care. Linked by advanced technology, Montefiore is a comprehensive and integrated health system that derives its inspiration for excellence from its patients and community. For more information, please visit www.montefiore.org and www.montekids.org and follow us on Twitter @MontefioreNews.
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Public release date: 20-Sep-2012[ | E-mail |
Share ] Contact: Kim Newman
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
September 20, 2012 (BRONX, NY) Why does cancer arise in certain parts of the body and not others? How exactly does it spread? These are critical questions that cannot be answered clearly despite decades of cancer research. Answers to complex but central questions about cancer have long stymied efforts to "win the war" on the disease.
Two research teams at Albert Einstein College of Medicine of Yeshiva University and Montefiore Medical Center , the University Hospital for Einstein, have each been awarded grants from the National Cancer Institute (NCI) as part of their "Provocative Questions" program. The innovative effort is designed to ignite investigations into 24 promising but neglected or unexplored areas of research. Answering the questions would dramatically enhance ongoing efforts to prevent, treat and cure the disease.
The Einstein-Montefiore grants two of only 57 given nationwide and only five in New York City, and totaling more than $3 million over the next five years are aimed at determining why cancer arises in certain tissues and how the disease spreads. Grant recipients are Steven Libutti, M.D. , Richard Kitsis, M.D. , John Condeelis, Ph.D. , Sumanta Goswami, Ph.D., and Maja Oktay, M.D., Ph.D.
Both research teams will leverage the shared resources and unique assets of the two institutions to tackle their research projects, tapping into the clinical opportunities at Montefiore Einstein Center for Cancer Care and the advanced technical resources at the Albert Einstein Cancer Center and the Gruss Lipper Biophotonics Center .
The first grant, awarded to Drs. Libutti and Kitsis, will investigate why certain mutations promote cancer in some tissues of the body but not in others. The researchers will try to identify the factors responsible for this phenomenon, which they call "tissue-selective tumorigenesis."
The model they'll be using in their study is a rare condition that results in human cancer called multiple endocrine neoplasia type 1 (MEN1). This inherited cancer results from a mutation in a gene called MEN1. Since MEN1 is a tumor suppressor gene, mutations in this gene permit tumors to occur. People with this cancer have a mutated MEN1 gene in every cell of their body, yet their tumors occur only in their endocrine glands (most often the parathyroid glands, the pancreas and the pituitary gland) and their duodenum (small intestine). The goal of this study is to discover why.
The researchers will take advantage of unique mouse models they developed and the fact that MEN1 tumors form only in the portion of the pancreas that produces insulin and other hormones and never in the "non-endocrine" part of the organ. Therefore, part of their research will involve comparing the two types of pancreatic tissue, looking for differences in gene expression.
The second team of grant recipients, consisting of Drs. Condeelis, Goswami and Oktay, will focus on developing new approaches to investigating the biology of metastasisthe usually fatal spread of the primary cancer to other parts of the body. Using human breast cancer cells obtained from tumors of patients treated at Montefiore Einstein Center for Cancer Care, the scientists will focus on intravasationthe crucial step in which tumor cells invade blood vessels and are then carried to distant sites where they become seeded in new tissues.
The researchers have hypothesized that different breast tumors contain varying proportions of cells capable of invading blood vessels and that these "intravasation-competent" cancer cells have distinct gene expression profiles. The proportion of such tumor cells and the genes they express would determine whether a breast tumor metastasizes or not.
The goal of the research is to develop a human intravasation "signature" that will predict whether a breast cancer tumor is destined to metastasize. Identifying this signature will help to reveal targets for anti-metastatic therapies. Such therapies are urgently needed to decrease the morbidity and mortality associated with breast cancer.
Dr. Libutti is director of the Montefiore Einstein Center for Cancer Care, associate director of clinical services at Albert Einstein Cancer Center , professor of surgery and of genetics at Einstein, and vice chair of surgery at Einstein and Montefiore. Dr. Kitsis holds the Dr. Gerald and Myra Dorros Chair in Cardiovascular Disease and is professor of medicine and of cell biology and the director of the Wilf Family Cardiovascular Research Institute at Einstein. Dr. Condeelis is professor and co-chair of anatomy and structural biology , co-director of the Gruss Lipper Biophotonics Center , leader of the program in tumor microenvironment and metastasis in the Albert Einstein Cancer Center , and holder of the Judith and Burton P. Resnick Chair in Translational Research at Einstein. Dr. Goswami is assistant professor of anatomy and structural biology at Einstein and associate professor of biology at Yeshiva University. Dr. Oktay is associate professor of pathology (clinical) at Einstein and attending physician, pathology at Montefiore.
The MEN1 grant (CA170911) is for $1.7 million over 5 years; the metastasis grant (CA170507) totals $1.4 million over 4 years. The preliminary work for the MEN1 grant was funded by a generous gift from Linda and Earle Altman to Dr. Libutti. The preliminary data that made the metastasis grant possible were obtained from a gift from the Dempsey Family to the Albert Einstein Cancer Center that was awarded to Dr. Oktay in the fall of 2011.
###
Albert Einstein College of Medicine
Albert Einstein College of Medicine of Yeshiva University is one of the nation's premier centers for research, medical education and clinical investigation. In 2011, Einstein received nearly $170 million in awards from the NIH for major research centers at Einstein in diabetes, cancer, liver disease, and AIDS, as well as other areas. Through its affiliation with Montefiore Medical Center, the University Hospital for Einstein, and six other hospital systems, the College of Medicine runs one of the largest post-graduate medical training programs in the United States, offering 155 residency programs to more than 2,200 physicians in training. For more information, please visit www.einstein.yu.edu and follow us on Twitter @EinsteinMed.
Montefiore Medical Center
As the University Hospital for Albert Einstein College of Medicine, Montefiore is a premier academic medical center nationally renowned for its clinical excellence, scientific discovery and commitment to its community. Montefiore is consistently recognized among the top hospitals nationally by U.S. News & World Report, and excels at educating tomorrow's healthcare professionals in superior clinical and humanistic care. Linked by advanced technology, Montefiore is a comprehensive and integrated health system that derives its inspiration for excellence from its patients and community. For more information, please visit www.montefiore.org and www.montekids.org and follow us on Twitter @MontefioreNews.
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Source: http://www.eurekalert.org/pub_releases/2012-09/aeco-esa091912.php
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